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The approach to fighting viruses just shifted entirely. For years, the model was one strain, one shot. Now, the NIH is building a universal platform. It doesn’t just target one virus. It targets whole families of them, including influenza and coronaviruses. The delivery method is changing, too. One intranasal candidate is designed to block transmission directly at the point of entry, rather than just preventing severe illness down the line. The science is incredibly ambitious. But the biggest hurdle has nothing to do with the lab. It is the collapse of public trust. A technological leap means nothing if millions refuse it on principle. The next era of pandemic response will not just test our medicine. It will test our society.